![]() An increased incidence of leukopenia has been reported in patients treated concurrently with cimetidine. Recovery is not influenced by continuation of silver sulfadiazine therapy. Rebound to normal leukocyte levels follows onset within 2 to 3 days. Maximal white blood cell depression occurs within 2 to 4 days of initiation of therapy. 1,2,3 Leukopenia associated with silver sulfadiazine administration is primarily characterized by decreased neutrophil count. Several cases of transient leukopenia have been reported in patients receiving silver sulfadiazine therapy. The use of silver sulfadiazine cream 1% in some cases of glucose-6-phosphate dehydrogenase-deficient individuals may be hazardous, as hemolysis may occur. However, the incidence of clinically reported fungal superinfection is low. If allergic reactions attributable to treatment with silver sulfadiazine occur, continuation of therapy must be weighed against the potential hazards of the particular allergic reaction.įungal proliferation in and below the eschar may occur. There is potential cross-sensitivity between silver sulfadiazine and other sulfonamides. Some of the reactions, which have been associated with sulfonamides, are as follows: blood dyscrasias including agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, and hemolytic anemia dermatologic and allergic reactions, including life-threatening cutaneous reactions gastrointestinal reactions hepatitis and hepatocellular necrosis CNS reactions and toxic nephrosis. Although few have been reported, it is possible that any adverse reaction associated with sulfonamides may occur. Silver sulfadiazine is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated.Ībsorption of silver sulfadiazine varies depending upon the percent of body surface area and the extent of the tissue damage. Apply once or twice daily with a sterile-gloved hand apply to a thickness of 1/16 " burned area should be covered with cream at all times.Results of In Vitro Testing with Silver Sulfadiazine Cream 1% Concentration of Silver Sulfadiazine Number of Sensitive Strains/Total Number of Strains Tested Genus & Species Patient instruction should be appropriate to extent of burn, patient understanding, etc. Usually applied by professional in burn care setting. Pregnant ladies and breastfeeding mothers should first consult their doctor before using this drug and exercise caution. Do not use this drug if you have a known history of allergy to it. Before using this medication, tell your healthcare professional about your allergies. If this happens, wash it with water immediately. Other than this, it can also cause minor burning or irritation at the application site.ĭo not let this medicine come in contact with your eyes, nose, or mouth. The most common side effect of this medication is decreased white blood cell count. It is recommended to use this drug regularly to get the maximum benefits.ĭo not use this drug more than the prescribed amount as it can increase the risk of adverse reaction. The dose and duration should be used as prescribed by the doctor. The wound must be cleaned properly before applying this cream. This drug must be used only on the burnt area of the skin. The medication is meant to be used externally only. ![]() This drug is a type of an antibiotic which helps in treating bacterial infection by inhibiting the bacteria from growing. Silver Sulfadiazine Cream is helpful in preventing and treating of infection in second and third degree skin burns.
0 Comments
Leave a Reply. |